Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

Die vorliegende Arbeit zielt darauf ab, Momente der Husserlschen Phänomenologie hervorzuheben, in denen diese an ihre Grenzen stößt. Der Ausweis dieser Grenzphänomene, die in der Husserl-Literatur bisher noch nicht systematisch untersucht worden sind, steht im Zentrum der Arbeit. Der Autor hat sich systematisch mit phänomenologisch orientierten Autoren zeitgenössischer Philosophie auseinandergesetzt u. a. mit der Absicht, die Fruchtbarkeit der Husserlschen Analysen für die zeitgenössische Philosophie hervorzuheben.

On the underwater environment and the mechanisms of deterioration of the materials likely to found on a shipwreck, and the theory and practice of conserving the artifacts recovered. Covers on-site storage, transport of artifacts, and requirements for exhibition after conservation treatment. Di Stefano (political science, U. of Washington) offers a new perspective on the dimension of gender in modern political thought in order to elucidate what is specifically masculine in political theory. Attempting to clear some conceptual space for feminist (...) political theory, she provides critical readings of Hobbes, Marx, and J.S. Mill. Annotation copyrighted by Book News, Inc., Portland, OR. (shrink)

dolce, the first top-level ontology to be axiomatized, has remained stable for twenty years and today is broadly used in a variety of domains. dolce is inspired by cognitive and linguistic considerations and aims to model a commonsense view of reality, like the one human beings exploit in everyday life in areas as diverse as socio-technical systems, manufacturing, financial transactions and cultural heritage. dolce clearly lists the ontological choices it is based upon, relies on philosophical principles, is richly formalized, and (...) is built according to well-established ontological methodologies, e.g. OntoClean. Because of these features, it has inspired most of the existing top-level ontologies and has been used to develop or improve standards and public domain resources. Being a foundational ontology, dolce is not directly concerned with domain knowledge. Its purpose is to provide the general categories and relations needed to give a coherent view of reality, to integrate domain knowledge, and to mediate across domains. In these 20 years dolce has shown that applied ontologies can be stable and that interoperability across reference and domain ontologies is a reality. This paper briefly introduces the ontology and shows how to use it on a few modeling cases. (shrink)

In current philosophical discussions on evidence in the medical sciences, epidemiology has been used to exemplify a specific version of evidential pluralism. According to this view, known as the Russo–Williamson Thesis, evidence of both difference-making and mechanisms is produced to make causal claims in the health sciences. In this paper, I present an analysis of data and evidence in epidemiological practice, with a special focus on research on the exposome, and I cast doubt on the extent to which evidential pluralism (...) holds in this case. I start by focusing on the claim that molecular data allows for the production of mechanistic evidence. On the basis of a close look at the ways in which molecular data is used in exposome research, I caution against interpretations in terms of mechanistic evidence. Secondly, I expand my critical remarks on the thesis by addressing the conditions under which data is categorised as evidence in exposome research. I argue that these show that the classification of a dataset as a type of evidence is dependent on the ways in which the data is used. This is in contrast with the approach of evidential pluralism, where evidence is classified in different types on the basis of its intrinsic properties. Finally, I come back to what I consider the core of the thesis and suggest that the epidemiological research analysed in the paper indicates different interpretations of evidential pluralism and its applicability in the health sciences. (shrink)

Digital technologies hold promise to modernize healthcare. Such opportunity should be leveraged also to address the needs of rapidly ageing populations. Against this backdrop, this paper examines the use of wearable devices for promoting healthy ageing. Previous work has assessed the prospects of digital technologies for health promotion and disease prevention in older adults. However, to our knowledge, ours is one of the first attempts to specifically address the use of wearables for healthy ageing, and to offer ethical insights for (...) assessing the prospects of leveraging wearable devices in this context. We provide an analysis of the considerable opportunities associated with the use of wearables for healthy ageing, with a focus on the five domains of intrinsic capacity: locomotion, sensory functions, psychological aspects, cognition, and vitality. We then highlight current limitations and ethical challenges of such approach to healthy ageing, including issues related to access, inclusion, privacy, surveillance, autonomy, and regulation. We conclude by discussing the implications of our analysis in light of current debates on the ethics of digital health, and suggest measures to address the identified challenges. (shrink)

In this commentary, I propose a framework for thinking about data quality in the context of scientific research. I start by analyzing conceptualizations of quality as a property of information, evidence and data and reviewing research in the philosophy of information, the philosophy of science and the philosophy of biomedicine. I identify a push for purpose dependency as one of the main results of this review. On this basis, I present a contextual approach to data quality in scientific research, whereby (...) the quality of a dataset is dependent on the context of use of the dataset as much as the dataset itself. I exemplify the approach by discussing current critiques and debates of scientific quality, thus showcasing how data quality can be approached contextually. (shrink)

In this paper, we analyse the relation between the use of environmental data in contemporary health sciences and related conceptualisations and operationalisations of the notion of environment. We consider three case studies that exemplify a different selection of environmental data and mode of data integration in data-intensive epidemiology. We argue that the diversification of data sources, their increase in scale and scope, and the application of novel analytic tools have brought about three significant conceptual shifts. First, we discuss the EXPOsOMICS (...) project, an attempt to integrate genomic and environmental data which suggests a reframing of the boundaries between external and internal environments. Second, we explore the MEDMI platform, whose efforts to combine health, environmental and climate data instantiate a reframing and expansion of environmental exposure. Third, we illustrate how extracting epidemiological insights from extensive social data collected by the CIDACS institute yields innovative attributions of causal power to environmental factors. Identifying these shifts highlights the benefits and opportunities of new environmental data, as well as the challenges that such tools bring to understanding and fostering health. It also emphasises the constraints that data selection and accessibility pose to scientific imagination, including how researchers frame key concepts in health-related research. (shrink)

Wearable devices are increasingly present in the health context, as tools for biomedical research and clinical care. In this context, wearables are considered key tools for a more digital, personalised, preventive medicine. At the same time, wearables have also been associated with issues and risks, such as those connected to privacy and data sharing. Yet, discussions in the literature have mostly focused on either technical or ethical considerations, framing these as largely separate areas of discussion, and the contribution of wearables (...) to the collection, development, application of biomedical knowledge has only partially been discussed. To fill in these gaps, in this article we provide an epistemic (knowledgerelated) overview of the main functions of wearable technology for health: monitoring, screening, detection, and prediction. On this basis, we identify 4 areas of concern in the application of wearables for these functions: data quality, balanced estimations, health equity, and fairness. To move the field forward in an effective and beneficial direction, we present recommendations for the 4 areas: local standards of quality, interoperability, access, and representativity. (shrink)

How is scientific data used to represent phenomena and as evidence for claims about phenomena? In this paper, I propose that a specific type of claims – evidential claims – is involved in data practices to define and restrict the representational and evidential content of a dataset. I present an account of data practices in the epidemiology of the exposome based on the notion of evidential claims, which helps unpack the approaches, assumptions and warrants that connect different stages of research. (...) I identify three different strategies to generate different types of evidential claims in this case. The macro strategy, which individuates the dataset that serves as the initial evidential space for research. The micro strategy, which is used to generate evidential claims about the microscopic and individual component of target phenomena. The association strategy, that uses evidence from the other strategies to identify a dataset as representation of the different levels and relations of exposure and disease. Differentiating between these strategies sheds light on the multi-faceted landscape of biomedical research on environment and health; and the roles of data and evidence in the process of inquiry. (shrink)

In this commentary, I discuss the scientific changes brought by the exposome, asking what is new about this approach and line of research. I place the exposome in a historical perspective, by analyzing the conditions under which the exposome has been conceived, developed and established in the context of contemporary epidemiological research. I argue that the exposome has been developed by transferring approaches, methods and conceptualizations from other lines of research in the life and health sciences. I thus discuss the (...) conceptual and methodological innovations of the exposome as a result of the merging and adaptation of these elements for new uses and purposes. On this basis, I argue that the novelty of the exposome should be seen in incremental rather than revolutionary terms and, in this sense, the exposome shares significant elements with other projects and repertoires in postgenomics. I conclude by discussing the consequences of this analysis for the potential limitations and future development of exposome research. (shrink)

I propose an approach that expands philosophical views of scientific change, on the basis of an analysis of contemporary biomedical research and recent developments in the philosophy of scientific change. Focusing on the establishment of the exposome in epidemiology as a case study and the role of data as a context for contrasting views on change, I discuss change at conceptual, methodological, material, and social levels of biomedical epistemology. Available models of change provide key resources to discuss this type of (...) change, but I present the need for an approach that models transfer, alignment, and influence as key processes of change. I develop this as a pragmatic approach to scientific change, where processes might change substantially depending on specific circumstances, thus contributing to and complementing the debate on a crucial epistemological issue. (shrink)

Humans are always interested in distinguishing natural and artificial entities although there is no sharp demarcation between the two categories. Surprisingly, things do not improve when the second type of entities is restricted to the arguably more constrained realm of physical technical artifacts. This paper helps to clarify the relationship between natural entities and technical artifacts by developing a conceptual landscape within which to analyze these notions. The framework is developed by studying three definitions of technical artifact which arise from (...) different perspectives. All these perspectives share two intuitions: that technical artifacts are physical objects that exist by human intervention; and that technical artifacts are entities to be contrasted to natural entities. Yet the perspectives are different in the way they spell out these intuitions: the relevant human intervention may range from intentional selection to intentional production; and the contrast between technical artifacts and natural entities may be introduced by a constitution relation or by defining properties that set technical artifacts apart. The three perspectives are compared and their similarities and dissimilarities are explored with the help of ontological analysis. (shrink)

Calls for evidence-based approaches to COVID-19 have sparked up discussions on the use of evidence for policy. In this note, we expand these discussions: while the debate has mostly focused on the types of evidence to be used for policy, we argue that the assessment of judgments involved in data practices and evidence production should play a central role in evaluating policy.

Purpose The purpose of this paper is to explore the epistemological tensions embedded within big data and data-driven technologies to advance a socio-political reconsideration of the public dimension in the assessment of their implementation. Design/methodology/approach This paper builds upon (and revisits) the European Union’s (EU) normative understanding of artificial intelligence (AI) and data-driven technologies, blending reflections rooted in philosophy of technology with issues of democratic participation in tech-related matters. Findings This paper proposes the conceptual design of sectorial and/or local-level e-participation (...) platforms to ignite an ongoing discussion – involving experts, private actors, as well as cognizant citizens – over the implementation of data-driven technologies, to avoid siloed, tech-solutionist decisions. Originality/value This paper inscribes the EU’s normative approach to AI and data-driven technologies, as well as critical work on the governance of these technologies, into a broader political dimension, suggesting a way to democratically and epistocratically opening up the decisional processes over the development and implementation of these technologies and turn such processes into a systemic civic involvement. (shrink)

Purpose This study advances a reconceptualization of data and information which overcomes normative understandings often contained in data policies at national and international levels. This study aims to propose a conceptual framework that moves beyond subject- and collective-centric normative understandings. Design/methodology/approach To do so, this study discusses the European Union (EU) and China’s approaches to data-driven technologies highlighting their similarities and differences when it comes to the vision underpinning how tech innovation is shaped. Findings Regardless of the different attention to (...) the subject (the EU) and the collective (China), the normative understandings of technology by both actors remain trapped into a positivist approach that overlooks all that is not and cannot be turned into data, thus hindering the elaboration of a more holistic ecological thinking merging humans and technologies. Originality/value Revising the philosophical and political debate on data and data-driven technologies, a third way is elaborated, i.e. federated data as commons. This third way puts the subject as part by default of a collective at the centre of discussion. This framing can serve as the basis for elaborating sociotechnical alternatives when it comes to define and regulate the mash-up of humans and technology. (shrink)

El objetivo del presente artículo es analizar la fenomenología de la donación de Jean- Luc Marion y plantear algunas críticas de carácter fenomenológico-hermenéutico. En primer lugar, se quiere mostrar cómo las interpretaciones que el pensador francés elabora de la donación en el «primer Heidegger» están claramente influenciadas por la filosofía del así llamado «segundo Heidegger» y, por tanto, pierden de vista el trasfondo hermenéutico que anima toda investigación heideggeriana de la década de 1920. En segundo lugar, se pondrá de manifiesto (...) cómo una fenomenología de la donación que reconduzca toda manifestación al puro darse de los fenómenos responde más a una problemática de carácter teorético-metafísico que a un planteamiento propiamente fenomenológico o hermenéutico. (shrink)

In this essay, I challenge the use of Conceptual Metaphor Theory in the premodern Chinese setting. The dominant, implicit assumption in the literature is that conclusions reached by CMT on the ways in which cognition operates can be applied in toto and without qualification onto the makers of classical Chinese texts. I want to challenge this assumption and argue that textual evidence from premodern Chinese points to a different cognitive process. Differences in the use and conceptualization of image-based thinking as (...) well as differences in the understanding of the relationship between words, images, and the world reveal a different cognitive process. However, I do not wish to argue for a total abandonment of the insights of CMT. Rather, I call for the need to properly qualify its findings in light of premodern Chinese use and conceptions of image-based language. (shrink)

We show that logic has more to offer to ontologists than standard first order and modal operators. We first describe some operators of linear logic which we believe are particularly suitable for ontological modeling, and suggest how to interpret them within an ontological framework. After showing how they can coexist with those of classical logic, we analyze three notions of artifact from the literature to conclude that these linear operators allow for reducing the ontological commitment needed for their formalization, and (...) even simplify their logical formulation. (shrink)

This book seeks to rectify misrepresentations of Popperian thought with a historical approach to Popper’s philosophy, an approach which applies his own mature view, that we gain knowledge through conjectures and refutations, to his own development, by portraying him in his intellectual growth as just such a series. Gattei seeks to reconstruct the logic of Popper’s development, in order to show how one problem and its tentative solution led to a new problem.

The discussion on the 900 Conclusiones projected and sponsored by Giovanni Pico della Mirandola in Rome was cut short by the condemnation of 13 of them by the papal commission in 1487. Princeps Concordiae’s counter-arguments presented in his Apologia, published in the same year, can not be certainly considered a disputatio as Pico had called for; the papal intervention removed in this way the possibility to have a better acquaintance with a work which is still a very difficult one, just (...) for its “unfinished” form. Pedro Garsia’s Determinationes magistrales against Pico’s Apologia are a very poor reply to Pico. In this paper Pico’s arguments against some of the condemned Conclusiones are considered as well as Pedro Garsia’s counter-arguments. Giovanni Pico della Mirandola displays a deep familiarity with medieval logical and semantical doctrines, while Pedro Garsia’s arguments betray a solid ignorance. (shrink)

Despite his well‐known deductivism, in his early (unpublished) writings, Popper held an inductivist position. Up to 1929 epistemology entered Popper's reflections only as far as the problem was that of the justification of the scientific character of these fields of research. However, in that year, while surveying the history of non‐Euclidean geometries, Popper explicitly discussed the cognitive status of geometry without referring to psycho‐pedagogical aspects, thus turning from cognitive psychology to the logic and methodology of science. As a consequence of (...) his reflections on the problematic relationship between geometrical‐mathematical constructions and physical reality Popper was able to get over a too direct notion of such a relationship, cast doubts on inductive inference and started conceiving in a new (strictly non‐inductivist) manner the relationship between theoretical and observational propositions. (shrink)

Comment une nouvelle divinité, munie de ses attributs spécifiques, ses timai et ses épiphanies, peut-elle être créée? Par qui? Et à quelles fins? Qui seront ses prêtres et ses fidèles? La documentation hellénistique confère une perspective historique aux aspects cultuels, sociaux et idéologiques de ces phénomènes religieux et les cultes des souverains sont un cas particulier de l’établissement et de l’acceptation de nouveaux dieux. Les cultes de souveraines n’ont que très récemment reçu l’attention qu’ils méritent. L’article étudie les cas de (...) Bérénice Ire, Arsinoé II et Laodice V afin de fournir de nouvelles interprétations de quelques fêtes dynastiques et d’étudier la relation entre les cultes de souverains et la légitima­tion du pouvoir féminin. La discussion repose surtout sur des papyrus et des inscriptions, mais l’analyse conclusive de l’Idylle XVII de Théocrite montre que la logique poétique de la légitimation du pouvoir entre en résonance avec celle qu’attestent les sources non littéraires. (shrink)

This paper is the written version of my contribution to the International Conference «30 years Logica modernorum» held in Amsterdam in November 1997 in honor of the late prof. Lambertus M. de Rijk. Research on Oresme’s modi rerum theory was in the first stage, while now we can read the critical edition of Oresme’s Physics commentary, where modi are introduced and widely used. In this paper I shall consider Oresme’s polemical use of modi rerum, trying to set it in the (...) larger context of both his ontology and his epistemology. Oresme’s challenge to either a realist or terminist ontology by means of modi rerum conceals probably an attack to William of Ockham; Oresme refers explicitly to Ockham concerning exclusive propositions, but I think that on many other occasions the polemical target of Oresme’s criticism can be reasonably identified in William of Ockham or in some unnamed followers of the Venerabilis Inceptor. Some hints are reserved also to the possible sources of Oresme’s modi rerum. (shrink)

Orazio Ricasoli Rucellai is one of the leading eruditi of the second half of 17th-century Florence; he tried to keep alive Galileo’s contribution to science. Most of his Dialoghi filosofici have been published at the end of 19th century; among the unpublished dialogues dedicated to Timaeus we find a partial defence of Descartes’ metaphysics, which is edited in the Appendix. In particular, the topics at stake are the demonstration of God’s existence and of the immateriality of the soul in Descartes’s (...) Meditationes. The opponent of Descartes’s doctrine relies on Gassendi’s Obiectiones. Descartes’s doctrine of ideas completely detached from sense perception is dismissed as useless on a cognitive basis, and only a generic innatism is maintained, only as far as it can provide a proof of God’s imprint on human soul. (shrink)

This volume features forty-two essays written in honor of Joseph Agassi. It explores the work and legacy of this influential philosopher, an exciting and challenging advocate of critical rationalism. Throughout six decades of stupendous intellectual activity, Agassi called attention to rationality as the very starting point of every notable philosophical way of life. The essays present Agassi’s own views on critical rationalism. They also develop and expand upon his work in new and provocative ways. The authors include Agassi's most notable (...) pupils, friends, and colleagues. Overall, their contributions challenge the received view on a variety of issues concerning science, religion, and education. Readers will find well-reasoned arguments on such topics as the secular problem of evil, religion and critical thinking, liberal democratic educational communities, democracy and constitutionalism, and capitalism at a crossroad.“/div>divTo Joseph Agassi, philosophy is the practice of reason, where reason is understood as the relentless search for criticisms of the best available explanations that we have to the world around us. This book not only honors one of the most original philosophers of science today. It also offers readers insights into a school of thought that lies at the heart of philosophy. (shrink)

This book seeks to rectify misrepresentations of Popperian thought with a historical approach to Popper’s philosophy, an approach which applies his own mature view, that we gain knowledge through conjectures and refutations, to his own development, by portraying him in his intellectual growth as just such a series. Gattei seeks to reconstruct the logic of Popper’s development, in order to show how one problem and its tentative solution led to a new problem.

_Abstract_: Nudges have proven to be effective tools for steering citizens toward desirable behaviors and make valuable additions to any policy-maker’s toolbox. Disappointingly, however, there are no mechanistic explanations for how nudges work, leaving policy-makers unable to explain what happens when they are implemented. This paper identifies some neglected ethical implications of the resulting citizens lack of awareness of such mechanisms. We first examine mechanistic explanations in relation to citizens’ understanding on how they work. Then, we look at mechanistic explanations (...) in light of the suggestion advanced by some ethicists that nudges be considered ethically acceptable in modern liberal democracies provided the explicit transparency of the nudges employed. _Keywords_: Nudge; Ethics of Nudging; Mechanistic Evidence; In-principle Transparency; Explicit Transparency _Spiegazioni meccanicistiche e l’etica dei _nudges _Riassunto_: I _nudge_ si sono rivelati strumenti di _policy_ efficaci nello "spingere gentilmente" i cittadini verso comportamenti considerati desiderabili. Per questa ragione i nudge sono considerati validi strumenti della cassetta degli attrezzi di un _policymaker_. Tuttavia, è in qualche modo deludente la mancanza di spiegazioni meccanicistiche dei nudge, dalla quale risulta l'incapacità dei _policymaker_ di spiegare quello che succede quando i nudge vengono effettivamente implementati. Questo articolo identifica alcune implicazioni etiche finora trascurate connesse alla inconsapevolezza da parte dei cittadini circa i meccanismi che governano i _nudge_. Da una parte, le nostre considerazioni metteranno in relazione le spiegazioni meccanicistiche con la comprensione dei _nudge_ da parte dei cittadini. Dall'altra parte, metteremo in relazione le spiegazioni meccanicistiche con il concetto di trasparenza esplicita, ossia la richiesta avanzata da alcuni eticisti al fine di considerare i _nudge_ eticamente accettabili nelle moderne democrazie liberali. _Parole chiave_: Nudge; Etica dei nudge; Spiegazioni meccanicistiche; Trasparenza implicita; Trasparenza esplicita. (shrink)

Name der Zeitschrift: Logic and Logical Philosophy Jahrgang: 22 Heft: 3 Seiten: 255-293.

Since 1537 Marco Antonio Zimara’s Tabula cum dilucidationibus in dictis Aristotelis et Averrois has been one of the most efficient and largely used instruments for a swift and at the same time precise access to the philosophical topics discussed in Aristotle’s works and in Averroes’ commentaries as well. In this paper the long and laborious gestation of Zimara’s Tabula is taken into account, starting with the notes in a 1507 edition of Aristotle’s works.